Research Compound · PPAR-Delta Agonist
Buy Cardarine (GW-501516) — Research-Grade, COA Verified
Cardarine (GW-501516, GW1516) is a PPAR-delta receptor agonist — one of the most studied research compounds for endurance, fat oxidation, and metabolic modulation in preclinical models. Independently tested to ≥99% purity via HPLC and Mass Spectrometry by MZ Biolabs. Available in liquid, capsules, and raw powder. Free shipping on orders over $100.
What Is Cardarine? The Most Studied PPAR-Delta Agonist in Research
Research Compound Overview
Cardarine (GW-501516, GW1516, Endurobol) is a synthetic PPAR-delta (peroxisome proliferator-activated receptor delta) agonist originally developed in the 1990s by GlaxoSmithKline and Ligand Pharmaceuticals. Despite being frequently grouped with SARMs in research compound catalogues, Cardarine has no androgen receptor binding activity — it operates through an entirely different mechanism via PPAR-delta nuclear receptor activation.
When you buy Cardarine from PureRawz, every batch is independently verified to ≥99% purity via HPLC and Mass Spectrometry by MZ Biolabs. The Certificate of Analysis for every batch is published publicly on the product page and searchable by lot number.
Cardarine (GW-501516) is consistently mislabeled as a SARM across the research compound market. It is not. It is a PPAR-delta receptor agonist — a nuclear receptor modulator with no androgen receptor activity. Its mechanism is closer to compounds like SR9009 (Rev-Erb agonist) than to RAD 140 or LGD-4033. This distinction is critical for accurate research protocol design and compound selection.
Cardarine Product Specifications
| Compound Name | Cardarine (GW-501516, GW1516, Endurobol) |
| Class | PPAR-delta Receptor Agonist (Nuclear Receptor) |
| Molecular Formula | C₂₁H₁₈F₃NO₃S₂ |
| Molecular Weight | 453.50 g/mol |
| CAS Number | 317318-70-0 |
| Purity (PureRawz) | ≥99% HPLC verified |
| Testing Lab | MZ Biolabs (independent, third-party) |
| Half-Life (animal) | ~16–24 hours (oral) |
| Available Forms | Liquid · Capsules · Powder |
| Storage | Cool, dry place away from direct light |
| Intended Use | Research purposes only — not for human use |
Pricing Guide
| Liquid 30ml | $29.99 |
| Liquid 60ml | $54.97 |
| Capsules 60ct | $59.99 |
| Powder 1g | $41.99 |
| Bulk 5g | $184.99 |
| Free Shipping | Orders over $100 |
Use code PURERAWZ20 for 20% off your first order.
Buy Cardarine in Multiple Research Forms
PureRawz offers Cardarine in three delivery formats. All forms use the same ≥99% purity compound with batch-specific third-party COA documentation.
Pre-suspended Cardarine in carrier solution at a precise concentration. Ready for immediate research use. Available in 30ml and 60ml amber glass vials with calibrated dropper for accurate dosing.
Pre-measured oral capsules delivering a consistent, exact dose per serving. Ideal for long-duration research protocols where daily dosing consistency and convenience are priorities.
Pure Cardarine powder for researchers requiring custom concentrations or novel formulations. Best cost-per-milligram ratio. Available in 1g and bulk 5g quantities for extended programs.
Cardarine vs SR9009 vs Ostarine — Which Research Compound?
Cardarine is most frequently compared to SR9009 and other endurance-focused research compounds. The table below highlights key distinctions based on published preclinical data.
| Factor | Cardarine (GW-501516) | SR9009 | Ostarine MK-2866 |
|---|---|---|---|
| Compound Class | PPAR-delta agonist | Rev-Erb agonist | SARM (AR agonist) |
| Receptor Target | PPAR-delta | Rev-Erb α/β | Androgen Receptor |
| Androgen Activity | None | None | Yes (selective) |
| Endurance Research | Extensive | Yes | Limited |
| Fat Oxidation Data | Extensive | Yes | Moderate |
| Muscle Preservation | Moderate | Limited | Extensive |
| Oral Bioavailability | High | Low (animal) | High |
| Half-Life (animal) | ~16–24 hours | ~4–5 hours | ~24 hours |
| PureRawz Price | From $29.99 | From $29.99 | From $29.99 |
All data reflects preclinical animal model findings only. Not applicable to human use.
Why Researchers Buy Cardarine From PureRawz
Cardarine is one of the most in-demand research compounds — and one of the most frequently counterfeited. PureRawz holds three non-negotiable standards.
Every Cardarine batch is tested by MZ Biolabs — accredited, independent, third-party. The COA is published publicly on every product page, searchable by lot number. No exceptions, no generic documents.
HPLC and Mass Spectrometry confirm purity and compound identity on every batch. Full impurity profiles documented. Cardarine’s PPAR-delta activity is entirely dependent on compound purity — an impure vial means unreliable research data.
Manufactured and fulfilled from a US facility. Orders before 2PM EST ship same business day. Domestic delivery in 2–4 business days. Discreet, unmarked packaging on every order.
Cardarine Research: What the Preclinical Data Shows
Cardarine was abandoned by its developers in 2007 after animal studies raised safety concerns at high doses over extended periods. However, its preclinical data across endurance, metabolism, and fat oxidation models remains among the most cited in the research compound literature. All data reflects animal model and in vitro findings. Cardarine is not approved for human use.
Why Cardarine’s Development Was Discontinued
GSK halted Cardarine development in 2007 after preclinical studies in rodents at high doses over extended periods showed accelerated tumor growth in multiple tissue types. These findings are important context for any research protocol design. The doses and durations in those studies are documented in the published literature and should be reviewed by any researcher working with this compound.
Primary Research Areas (Animal Models)
- Endurance & Exercise Capacity: The most cited Cardarine research area. Rodent models show dramatic improvements in exercise capacity and running distance via PPAR-delta activation in skeletal muscle — upregulating genes involved in fatty acid oxidation and mitochondrial biogenesis.
- Fat Oxidation & Metabolic Switching: PPAR-delta activation by Cardarine shifts energy substrate utilization toward fat oxidation in animal models — reducing reliance on glycogen and increasing fatty acid consumption during sustained activity.
- Lipid Profile Modulation: Animal and limited early human data show Cardarine improves HDL cholesterol and reduces LDL and triglycerides — making it a subject of interest in dyslipidemia and cardiovascular metabolic research.
- Insulin Sensitivity: Preclinical data shows Cardarine improves insulin sensitivity in diet-induced obese rodent models via PPAR-delta mediated glucose uptake pathways in skeletal muscle.
- Anti-Inflammatory Research: PPAR-delta activation by Cardarine reduces inflammatory gene expression in macrophages and vascular tissue in animal models — studied in the context of atherosclerosis and inflammatory metabolic disease research.
- Muscle Fiber Composition: Animal data suggests Cardarine promotes a shift toward Type I (oxidative) muscle fiber phenotype — relevant for research into muscle adaptation and endurance capacity.
- Combination Endurance Research: Cardarine is one of the most frequently combined compounds in preclinical endurance research — often paired with RAD 140, SR9009, or Ostarine in multi-compound metabolic protocols.
Cardarine Legal Status in 2026
Cardarine is legal to purchase in the United States as a research compound. It is not a controlled substance, not scheduled under the DEA, and does not require a prescription when purchased strictly for laboratory research. PureRawz sells Cardarine in full regulatory compliance — labeled for research use only, not for human or animal consumption.
Cardarine Research Dosage Reference — Animal Model Data Only
The following summarizes dosage ranges from published preclinical animal research. Provided for reference only. Not a recommendation for human use.
| Research Protocol | Reported Dose (Animal Models) | Route | Duration (Studies) |
|---|---|---|---|
| Endurance / Exercise Capacity | 5–10 mg/kg/day | Oral gavage | 4–8 weeks |
| Fat Oxidation / Metabolic | 3–10 mg/kg/day | Oral | 7–28 days |
| Lipid Profile Research | 2–10 mg/kg/day | Oral | 2–8 weeks |
| Insulin Sensitivity | 5–10 mg/kg/day | Oral gavage | 4–8 weeks |
| Anti-Inflammatory | 1–10 mg/kg | Oral or IP | Variable |
Data sourced from peer-reviewed preclinical literature. Human equivalent doses, safety, and efficacy are not established. Cardarine is not FDA-approved.
Buy Cardarine — Frequently Asked Questions
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