Epithalon

$57.39

Epithalon is a tetrapeptide studied for telomerase activation, pineal gland regulation, and anti-aging research in laboratory settings. 99% purity.

Availability: 999 in stock






Buy Epithalon | 99% Pure, COA Verified | PureRawz




Research Peptide · Telomerase Activator · Anti-Aging

Buy Epithalon — Research-Grade Telomere Peptide, COA Verified

≥99% Purity
Third-Party COA
USA Manufactured
Ships Same Day
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Epithalon (Epitalon) is a synthetic tetrapeptide with one of the most unique research profiles in the peptide space — the only research compound studied for direct telomerase activation and telomere elongation in animal models. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, with over 40 years of published preclinical and limited clinical research. Independently tested to ≥99% purity. Free shipping on orders over $100.

What Is Epithalon? The Only Peptide Studied for Telomere Elongation

Research Compound Overview

Epithalon (Epitalon, Epithalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG). It is derived from Epithalamin — a natural polypeptide extract from the pineal gland — and was developed as the synthetic bioactive core by Professor Vladimir Khavinson, whose research institution has published the majority of Epithalon’s preclinical literature over the past four decades.

Epithalon holds a unique position in research peptide science as the only compound with published data showing direct telomerase activation and telomere elongation in somatic cells — a mechanism directly linked to cellular aging in biological research. When you buy Epithalon from PureRawz, every batch is independently verified to ≥99% purity via HPLC and Mass Spectrometry by MZ Biolabs.

Epithalon vs Epithalamin — What Is the Difference?

Epithalamin is a naturally occurring polypeptide complex extracted from bovine pineal glands. It contains multiple bioactive peptides including Epithalon. Epithalon (Epitalon) is the synthetic tetrapeptide (Ala-Glu-Asp-Gly) identified and isolated by Professor Khavinson as the primary bioactive component of Epithalamin. Epithalon is more consistent batch-to-batch, more precisely characterized, and is the form used in the majority of modern preclinical research. PureRawz sells synthetic Epithalon — not natural Epithalamin extract.

Epithalon Product Specifications

Compound Name Epithalon (Epitalon, Epithalon, AEDG Peptide)
Sequence Ala-Glu-Asp-Gly (AEDG)
Class Synthetic Tetrapeptide / Telomerase Activator
Amino Acids 4
Molecular Formula C₁₄H₂₂N₄O₉
Molecular Weight 390.35 g/mol
CAS Number 307297-39-8
Developed by Prof. Vladimir Khavinson, St. Petersburg IBG
Purity (PureRawz) ≥99% HPLC verified
Testing Lab MZ Biolabs (independent, third-party)
Storage (lyophilized) −20°C long-term · 4°C short-term
Reconstituted Stability Up to 28 days refrigerated at 4°C
Available Forms Lyophilized Powder · Nasal Spray · Oral Capsules
Intended Use Research purposes only — not for human use
⚠️ Research Use Only: Epithalon sold by PureRawz is intended solely for in vitro laboratory and scientific research. It is not approved for human or animal consumption. Consult a qualified professional before any research application.

Pricing Guide

10mg lyophilized powder $29.99
20mg lyophilized powder $52.99
50mg lyophilized powder $109.99
100mg bulk $164.99
Nasal Spray From $39.99
Oral Capsules 60ct $49.99
Free Shipping Orders over $100

Use code PURERAWZ20 for 20% off your first order.


How Epithalon Works — The Telomerase Activation Pathway

Epithalon’s mechanism is unique among all research peptides. While most peptides work via receptor binding or signaling cascade modulation, Epithalon has been shown in animal and in vitro studies to act at the level of gene expression — specifically activating telomerase, the enzyme responsible for maintaining telomere length.

Epithalon’s Proposed Mechanism — 4 Steps
Step 1
Epithalon enters the cell nucleus and interacts with chromatin — the DNA-protein complex controlling gene expression.

Step 2
Epithalon activates telomerase expression — the enzyme that adds telomeric repeats (TTAGGG) to chromosome ends.

Step 3
Telomere length is maintained or elongated in somatic cells — countering the progressive shortening that occurs with each cell division.

Step 4
Cells with longer telomeres demonstrate extended replicative capacity and reduced markers of cellular senescence in animal models.

This telomere-based mechanism differentiates Epithalon from every other research peptide. No other compound in the research market has published data demonstrating direct telomerase activation in somatic cells. This is why Epithalon sits at the center of longevity and anti-aging peptide research in 2026.


Buy Epithalon in Multiple Research Forms

PureRawz offers Epithalon in three delivery formats. All forms use the same ≥99% purity compound with batch-specific third-party COA documentation.

❄️
Lyophilized Powder Most Popular

Freeze-dried Epithalon in sealed glass vials. Reconstitute with bacteriostatic water. Stable 24+ months at −20°C. The gold-standard format for subcutaneous research protocols. Available in 10mg, 20mg, 50mg, and bulk 100mg vials.

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Nasal Spray

Epithalon in intranasal delivery format using PureRawz’s proprietary suspension technology. Designed for research examining mucosal peptide absorption and systemic bioavailability via the nasal route. No reconstitution required.

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Oral Capsules

Epithalon in oral capsule form. Relevant for research examining gut-pathway bioavailability of short tetrapeptides. Pre-measured doses for consistent daily administration across long-duration longevity research protocols.


Epithalon vs Other Longevity Research Peptides

Epithalon sits within a growing category of longevity-focused research peptides. The table below compares it against the most frequently co-researched compounds in the anti-aging peptide space.

Factor Epithalon GHK-Cu BPC-157 TB-500
Primary Mechanism Telomerase activation Copper peptide / collagen Growth factor modulation Actin regulation
Telomere Research Yes — primary focus Limited No No
Anti-Aging Data Extensive (40+ years) Moderate Limited Limited
Pineal / Circadian Data Yes — significant No No No
Cancer Resistance Research Yes (animal models) Limited No No
Tissue Repair Data Moderate Yes Extensive Extensive
Amino Acids 4 (tetrapeptide) 3 (tripeptide) 15 43
PureRawz Price From $29.99 From $27.99 From $25.99 From $34.47

All data reflects preclinical animal model and in vitro findings only. Not applicable to human use.


Why Researchers Buy Epithalon From PureRawz

Epithalon’s small tetrapeptide structure makes synthesis straightforward — which unfortunately also makes it a common target for underdosed or low-purity products. PureRawz holds three non-negotiable standards.

01
Independent Third-Party Testing

Every Epithalon batch is tested by MZ Biolabs — accredited, independent, third-party. The COA is published publicly on every product page, searchable by lot number. No generic documents shared across batches.

02
≥99% Purity on Every Batch

HPLC and Mass Spectrometry confirm purity and sequence identity on every batch. For a tetrapeptide, sequence verification via Mass Spec is especially important — similar short peptides can be difficult to distinguish without identity confirmation.

03
USA-Made, Same-Day Shipping

Manufactured and fulfilled from a US facility. Orders before 2PM EST ship same business day. Domestic delivery in 2–4 business days. All peptide orders cold-packed where required. Discreet, unmarked packaging on every order.


Epithalon Research: 40 Years of Preclinical Data

Epithalon has one of the longest research histories of any synthetic peptide — with publications dating back to the 1980s from Professor Khavinson’s laboratory. The following summarizes primary research directions. All data reflects animal model and in vitro findings. Epithalon is not approved for human use.

Primary Research Areas

  • Telomerase Activation & Telomere Elongation: The defining Epithalon research finding. In vitro and animal model studies demonstrate Epithalon activates telomerase in somatic cells — maintaining and in some studies elongating telomere length. This is the only published data of its kind for any research peptide and is the primary driver of Epithalon’s anti-aging research interest.
  • Lifespan Extension (Animal Models): Fruit fly (Drosophila) and rodent studies show Epithalon administration extends mean and maximum lifespan in treated subjects vs controls. The Drosophila data is particularly well-replicated across multiple published studies from Khavinson’s group.
  • Pineal Gland & Melatonin Regulation: Epithalon was derived from pineal gland extract and demonstrates regulatory effects on pineal function in animal models — increasing melatonin production and normalizing disrupted circadian rhythms in aged subjects. This makes it unique among longevity peptides for circadian biology research.
  • Cancer Resistance Models: Animal model studies show Epithalon-treated subjects demonstrate reduced incidence of spontaneous tumor development and slower tumor growth compared to controls — an area of ongoing preclinical oncology-adjacent research.
  • Neuroendocrine Normalization: Epithalon demonstrates regulatory effects on neuroendocrine function in aged animal models — normalizing disrupted hormonal rhythms including cortisol, melatonin, and gonadotropin patterns associated with aging.
  • Retinal Repair Research: A particularly notable research direction — Epithalon has been studied in retinal degeneration models in both rodents and limited human case observations. Animal data shows regenerative effects on photoreceptor cells.
  • Immune System Modulation: Animal studies show Epithalon normalizes immune function in aged subjects — restoring T-cell activity and NK cell counts toward values seen in younger animals. Immunosenescence research is an active area of Epithalon study.
  • Antioxidant Activity: In vitro and animal data shows Epithalon reduces oxidative stress markers — decreasing lipid peroxidation and increasing superoxide dismutase and catalase activity in aged tissue models.

The Khavinson Research Legacy

Professor Vladimir Khavinson and the St. Petersburg Institute of Bioregulation and Gerontology have published over 800 papers on bioregulatory peptides — with Epithalon being the most studied. While the majority of this research comes from a single institution and requires independent replication, the volume and consistency of findings across four decades positions Epithalon as one of the most uniquely researched compounds in the anti-aging peptide category. Researchers should review the primary literature directly when designing protocols.

Epithalon Legal Status in 2026

Epithalon is legal to purchase in the United States as a research peptide. It is not a controlled substance, not scheduled under the DEA, and does not require a prescription when purchased strictly for laboratory research. PureRawz sells Epithalon in full regulatory compliance — labeled for research use only, not for human or animal consumption.


Epithalon Research Dosage Reference — Animal Model Data Only

The following summarizes dosage ranges from published preclinical research. Provided for reference only. Not a recommendation for human use.

Research Protocol Reported Dose (Animal Models) Route Duration (Studies)
Telomerase Activation (in vitro) 0.1–10 nM Cell culture 24–72 hours
Lifespan Extension (rodent) 0.1–1 mg/kg/day SC injection Cyclic (courses)
Melatonin / Pineal Research 0.5–1 mg/kg/day SC injection 10–20 days
Cancer Resistance (rodent) 0.1–1 mg/kg/day SC injection 5–10 day courses
Retinal Research (rodent) 0.5–1 mg/kg/day SC or subretinal 10–20 days
Immune Normalization 0.1–1 mg/kg/day SC injection 10 day courses

Data sourced from peer-reviewed preclinical literature, primarily from Khavinson et al. Human equivalent doses, safety, and efficacy are not established. Epithalon is not FDA-approved.


Buy Epithalon — Frequently Asked Questions

What makes Epithalon unique compared to other research peptides?
Epithalon is the only research compound with published data demonstrating direct telomerase activation and telomere elongation in somatic cells. Every other research peptide in the market works via receptor binding, signaling cascade modulation, or growth factor regulation. Epithalon works at the level of gene expression — specifically activating telomerase, the enzyme responsible for maintaining telomere length. Telomere shortening is one of the hallmarks of cellular aging, making this mechanism uniquely relevant to longevity and anti-aging research. No other peptide has this profile.

Epithalamin is a natural polypeptide complex extracted from bovine pineal glands containing multiple bioactive peptides. Epithalon (Epitalon) is the synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Professor Khavinson as the isolated bioactive core of Epithalamin. Epithalon is more batch-consistent, more precisely characterized, and is the form used in the majority of modern research. PureRawz sells synthetic Epithalon — not natural pineal extract.

Yes. Epithalon is legal to purchase in the United States as a research peptide. It is not a controlled substance, not scheduled under the DEA, and does not require a prescription when purchased strictly for research purposes. PureRawz sells Epithalon in full compliance with applicable regulations — labeled for research use only, not for human or animal consumption.

PureRawz Epithalon is independently verified at ≥99% purity via HPLC and Mass Spectrometry by MZ Biolabs, a third-party accredited laboratory. Every batch receives a batch-specific Certificate of Analysis published publicly on the product page and searchable by lot number. Mass Spectrometry sequence confirmation is included — important for tetrapeptides where similar short sequences could be difficult to distinguish by HPLC alone.

PureRawz offers Epithalon in three forms: lyophilized powder (most popular — freeze-dried in sealed glass vials, reconstituted with bacteriostatic water, stable 24+ months at −20°C; available in 10mg, 20mg, 50mg, and bulk 100mg), nasal spray (intranasal delivery for mucosal absorption research), and oral capsules (for gut-pathway bioavailability research). All forms carry the same ≥99% purity guarantee.

Lyophilized Epithalon stored at −20°C in a sealed vial is stable for 24+ months. At 4°C it remains stable for 6–12 months. Once reconstituted with bacteriostatic water, use within 28 days refrigerated at 4°C. Keep vials sealed and away from light, heat, and moisture until use. Never freeze reconstituted peptide solution.

Epithalon starts from $29.99 for a 10mg lyophilized powder vial. 20mg is $52.99, 50mg is $109.99, and bulk 100mg is $164.99. Nasal spray starts from $39.99 and oral capsules (60ct) are $49.99. Free shipping on orders over $100. Use code PURERAWZ20 for 20% off your first order.

Orders placed before 2PM EST ship same business day via USPS. Domestic US delivery typically takes 2–4 business days. A tracking number is emailed upon fulfillment. All peptide orders are cold-packed where required. International shipping is available with typical delivery of 8–17 business days. All orders ship in discreet, unmarked packaging.

PureRawz accepts major credit and debit cards, cryptocurrency (Bitcoin, Ethereum, and others), ACH bank transfer, Zelle, and Venmo. Cryptocurrency payments often qualify for additional discounts. All checkout sessions are encrypted and secure.


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