Research Peptide · Telomerase Activator · Anti-Aging
Buy Epithalon — Research-Grade Telomere Peptide, COA Verified
Epithalon (Epitalon) is a synthetic tetrapeptide with one of the most unique research profiles in the peptide space — the only research compound studied for direct telomerase activation and telomere elongation in animal models. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, with over 40 years of published preclinical and limited clinical research. Independently tested to ≥99% purity. Free shipping on orders over $100.
What Is Epithalon? The Only Peptide Studied for Telomere Elongation
Research Compound Overview
Epithalon (Epitalon, Epithalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG). It is derived from Epithalamin — a natural polypeptide extract from the pineal gland — and was developed as the synthetic bioactive core by Professor Vladimir Khavinson, whose research institution has published the majority of Epithalon’s preclinical literature over the past four decades.
Epithalon holds a unique position in research peptide science as the only compound with published data showing direct telomerase activation and telomere elongation in somatic cells — a mechanism directly linked to cellular aging in biological research. When you buy Epithalon from PureRawz, every batch is independently verified to ≥99% purity via HPLC and Mass Spectrometry by MZ Biolabs.
Epithalamin is a naturally occurring polypeptide complex extracted from bovine pineal glands. It contains multiple bioactive peptides including Epithalon. Epithalon (Epitalon) is the synthetic tetrapeptide (Ala-Glu-Asp-Gly) identified and isolated by Professor Khavinson as the primary bioactive component of Epithalamin. Epithalon is more consistent batch-to-batch, more precisely characterized, and is the form used in the majority of modern preclinical research. PureRawz sells synthetic Epithalon — not natural Epithalamin extract.
Epithalon Product Specifications
| Compound Name | Epithalon (Epitalon, Epithalon, AEDG Peptide) |
| Sequence | Ala-Glu-Asp-Gly (AEDG) |
| Class | Synthetic Tetrapeptide / Telomerase Activator |
| Amino Acids | 4 |
| Molecular Formula | C₁₄H₂₂N₄O₉ |
| Molecular Weight | 390.35 g/mol |
| CAS Number | 307297-39-8 |
| Developed by | Prof. Vladimir Khavinson, St. Petersburg IBG |
| Purity (PureRawz) | ≥99% HPLC verified |
| Testing Lab | MZ Biolabs (independent, third-party) |
| Storage (lyophilized) | −20°C long-term · 4°C short-term |
| Reconstituted Stability | Up to 28 days refrigerated at 4°C |
| Available Forms | Lyophilized Powder · Nasal Spray · Oral Capsules |
| Intended Use | Research purposes only — not for human use |
Pricing Guide
| 10mg lyophilized powder | $29.99 |
| 20mg lyophilized powder | $52.99 |
| 50mg lyophilized powder | $109.99 |
| 100mg bulk | $164.99 |
| Nasal Spray | From $39.99 |
| Oral Capsules 60ct | $49.99 |
| Free Shipping | Orders over $100 |
Use code PURERAWZ20 for 20% off your first order.
How Epithalon Works — The Telomerase Activation Pathway
Epithalon’s mechanism is unique among all research peptides. While most peptides work via receptor binding or signaling cascade modulation, Epithalon has been shown in animal and in vitro studies to act at the level of gene expression — specifically activating telomerase, the enzyme responsible for maintaining telomere length.
This telomere-based mechanism differentiates Epithalon from every other research peptide. No other compound in the research market has published data demonstrating direct telomerase activation in somatic cells. This is why Epithalon sits at the center of longevity and anti-aging peptide research in 2026.
Buy Epithalon in Multiple Research Forms
PureRawz offers Epithalon in three delivery formats. All forms use the same ≥99% purity compound with batch-specific third-party COA documentation.
Freeze-dried Epithalon in sealed glass vials. Reconstitute with bacteriostatic water. Stable 24+ months at −20°C. The gold-standard format for subcutaneous research protocols. Available in 10mg, 20mg, 50mg, and bulk 100mg vials.
Epithalon in intranasal delivery format using PureRawz’s proprietary suspension technology. Designed for research examining mucosal peptide absorption and systemic bioavailability via the nasal route. No reconstitution required.
Epithalon in oral capsule form. Relevant for research examining gut-pathway bioavailability of short tetrapeptides. Pre-measured doses for consistent daily administration across long-duration longevity research protocols.
Epithalon vs Other Longevity Research Peptides
Epithalon sits within a growing category of longevity-focused research peptides. The table below compares it against the most frequently co-researched compounds in the anti-aging peptide space.
| Factor | Epithalon | GHK-Cu | BPC-157 | TB-500 |
|---|---|---|---|---|
| Primary Mechanism | Telomerase activation | Copper peptide / collagen | Growth factor modulation | Actin regulation |
| Telomere Research | Yes — primary focus | Limited | No | No |
| Anti-Aging Data | Extensive (40+ years) | Moderate | Limited | Limited |
| Pineal / Circadian Data | Yes — significant | No | No | No |
| Cancer Resistance Research | Yes (animal models) | Limited | No | No |
| Tissue Repair Data | Moderate | Yes | Extensive | Extensive |
| Amino Acids | 4 (tetrapeptide) | 3 (tripeptide) | 15 | 43 |
| PureRawz Price | From $29.99 | From $27.99 | From $25.99 | From $34.47 |
All data reflects preclinical animal model and in vitro findings only. Not applicable to human use.
Why Researchers Buy Epithalon From PureRawz
Epithalon’s small tetrapeptide structure makes synthesis straightforward — which unfortunately also makes it a common target for underdosed or low-purity products. PureRawz holds three non-negotiable standards.
Every Epithalon batch is tested by MZ Biolabs — accredited, independent, third-party. The COA is published publicly on every product page, searchable by lot number. No generic documents shared across batches.
HPLC and Mass Spectrometry confirm purity and sequence identity on every batch. For a tetrapeptide, sequence verification via Mass Spec is especially important — similar short peptides can be difficult to distinguish without identity confirmation.
Manufactured and fulfilled from a US facility. Orders before 2PM EST ship same business day. Domestic delivery in 2–4 business days. All peptide orders cold-packed where required. Discreet, unmarked packaging on every order.
Epithalon Research: 40 Years of Preclinical Data
Epithalon has one of the longest research histories of any synthetic peptide — with publications dating back to the 1980s from Professor Khavinson’s laboratory. The following summarizes primary research directions. All data reflects animal model and in vitro findings. Epithalon is not approved for human use.
Primary Research Areas
- Telomerase Activation & Telomere Elongation: The defining Epithalon research finding. In vitro and animal model studies demonstrate Epithalon activates telomerase in somatic cells — maintaining and in some studies elongating telomere length. This is the only published data of its kind for any research peptide and is the primary driver of Epithalon’s anti-aging research interest.
- Lifespan Extension (Animal Models): Fruit fly (Drosophila) and rodent studies show Epithalon administration extends mean and maximum lifespan in treated subjects vs controls. The Drosophila data is particularly well-replicated across multiple published studies from Khavinson’s group.
- Pineal Gland & Melatonin Regulation: Epithalon was derived from pineal gland extract and demonstrates regulatory effects on pineal function in animal models — increasing melatonin production and normalizing disrupted circadian rhythms in aged subjects. This makes it unique among longevity peptides for circadian biology research.
- Cancer Resistance Models: Animal model studies show Epithalon-treated subjects demonstrate reduced incidence of spontaneous tumor development and slower tumor growth compared to controls — an area of ongoing preclinical oncology-adjacent research.
- Neuroendocrine Normalization: Epithalon demonstrates regulatory effects on neuroendocrine function in aged animal models — normalizing disrupted hormonal rhythms including cortisol, melatonin, and gonadotropin patterns associated with aging.
- Retinal Repair Research: A particularly notable research direction — Epithalon has been studied in retinal degeneration models in both rodents and limited human case observations. Animal data shows regenerative effects on photoreceptor cells.
- Immune System Modulation: Animal studies show Epithalon normalizes immune function in aged subjects — restoring T-cell activity and NK cell counts toward values seen in younger animals. Immunosenescence research is an active area of Epithalon study.
- Antioxidant Activity: In vitro and animal data shows Epithalon reduces oxidative stress markers — decreasing lipid peroxidation and increasing superoxide dismutase and catalase activity in aged tissue models.
The Khavinson Research Legacy
Professor Vladimir Khavinson and the St. Petersburg Institute of Bioregulation and Gerontology have published over 800 papers on bioregulatory peptides — with Epithalon being the most studied. While the majority of this research comes from a single institution and requires independent replication, the volume and consistency of findings across four decades positions Epithalon as one of the most uniquely researched compounds in the anti-aging peptide category. Researchers should review the primary literature directly when designing protocols.
Epithalon Legal Status in 2026
Epithalon is legal to purchase in the United States as a research peptide. It is not a controlled substance, not scheduled under the DEA, and does not require a prescription when purchased strictly for laboratory research. PureRawz sells Epithalon in full regulatory compliance — labeled for research use only, not for human or animal consumption.
Epithalon Research Dosage Reference — Animal Model Data Only
The following summarizes dosage ranges from published preclinical research. Provided for reference only. Not a recommendation for human use.
| Research Protocol | Reported Dose (Animal Models) | Route | Duration (Studies) |
|---|---|---|---|
| Telomerase Activation (in vitro) | 0.1–10 nM | Cell culture | 24–72 hours |
| Lifespan Extension (rodent) | 0.1–1 mg/kg/day | SC injection | Cyclic (courses) |
| Melatonin / Pineal Research | 0.5–1 mg/kg/day | SC injection | 10–20 days |
| Cancer Resistance (rodent) | 0.1–1 mg/kg/day | SC injection | 5–10 day courses |
| Retinal Research (rodent) | 0.5–1 mg/kg/day | SC or subretinal | 10–20 days |
| Immune Normalization | 0.1–1 mg/kg/day | SC injection | 10 day courses |
Data sourced from peer-reviewed preclinical literature, primarily from Khavinson et al. Human equivalent doses, safety, and efficacy are not established. Epithalon is not FDA-approved.
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